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Home / Die Pharmazie - An International Journal of Pharmaceutical Sciences, Volume 75, Number 5

Open Access Measurement of zinc concentration in blood and breast milk of a Wilson's disease patient taking zinc acetate

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Case: A 27-year-old, gravida 2, para 0, Japanese female who was maintained on zinc acetate (75 mg/day) during pregnancy expressed her desire to breastfeed after birth. We investigated the possibility of breastfeeding while on treatment. Breast milk zinc concentrations were determined using an atomic absorption photometer. Breast milk zinc concentrations on the 4th (colostrum) and 32nd (post-colostrum) days post partum were 10.80 μg/mL and 3.28 μg/mL, respectively. These values are less than the reported range of breast milk zinc concentrations in Japanese women who are not under any medication. Conclusion: We measured blood and breast milk zinc concentrations of a patient with Wilson's disease who was taking zinc acetate (75 mg/day). Zinc values were within the range of breast milk concentrations of mothers who are not on zinc acetate.

Document Type: Research Article

Affiliations: 1: Department of Pharmacy, University of the Ryukyus Hospital, Okinawa, Japan 2: Department of Obstetrics and Gynecology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan 3: Department of Pediatrics, Faculty of Medicine, University of the Ryukyus, Okinawa, Japan 4: Department of Pharmacy, University of the Ryukyus Hospital, Okinawa, Japan;, Email: [email protected]

Publication date: May 1, 2020

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