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Cyanidin-3-O-glucoside chloride acts synergistically with luteolin to inhibit the growth of colon and breast carcinoma cells

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In this study, we investigated whether the combination of cyanidin-3-O-glucoside chloride and luteolin could inhibit the growth of HCT-8 colon and MCF-7 breast carcinoma cells, and whether the effect of the combination was greater than the effect of either drug on its own. Growth inhibition was assessed using the CCK-8 assay, level of apoptosis and cell cycle distribution were determined using flow cytometry, and the mechanism of apoptosis induction was explored using a colorimetric assay of caspases-3 and -9. Experiments indicated that combination treatment inhibited proliferation and increased apoptosis in both cell lines to a greater extent than either drug on its own. These results suggest that luteolin and cyanidin-3-O-glucoside chloride synergistically inhibitthe growth of colon cancer and breast cancer cells. This work justifies further effort to develop this potential combination therapy.
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Document Type: Research Article

Publication date: January 1, 2019

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  • Pharmazie is a leading journal in the field of pharmaceutical sciences. As a peer-reviewed scientific journal, Pharmazie is regularly indexed in the relevant databases like Web of science, Journal Citation Reports and many others. The journal is open for submissions from the whole spectrum of pharnaceutical sciences including Pharmaceutical Chemistry, Experimental and Clinical Pharmacology, Drug Analysis, Pharmaceutics, Pharmaceutical Biology, Clinical Pharmacy etc.
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