Skip to main content
padlock icon - secure page this page is secure

Open Access Antiherpetic activity of the traditionally used complex essential oil Olbas®

Download Article:
(PDF 239.2 kb)
Essential oils of medicinal plants are increasingly of interest as novel drugs for antiherpetic agents, since herpes simplex virus (HSV) might develop resistance to commonly used antiviral drugs. The antiviral effect of Olbas®, a traditionally used complex essential oil, and of cajuput oil, a major constitutent of Olbas®, against HSV type 1 was examined. The antiviral activity of these essential oils was tested in vitro on monkey kidney cells using a plaque reduction assay. The 50% inhibitory concentration (IC50) of Olbas® and cajuput oil for herpes simplex virus plaque formation was determined at 1.8 μg/ml and 7.5 μg/ml, respectively. At noncytotoxic concentrations of these oils, plaque formation was significantly reduced by 99% for Olbas® and 66% for cajuput oil. The selectivity index of 150 for Olbas® against herpes simplex virus was superior to a rather low selectivity index for cajuput oil. The mode of antiviral action of these essential oils was assessed by time-on-addition assays. Herpesvirus was significantly inhibited by pretreatment with Olbas® essential oil prior to infection of cells. These results indicate that Olbas® affected the virus before adsorption, but not after penetration into the host cell, thus Olbas® exerted a direct antiviral effect on HSV. A clearly time-dependent antiviral activity for Olbas® and cajuput oil could be demonstrated. Considering the lipophilic nature of the Olbas® complex essential oil mixture, which enables it to penetrate the skin, and a high selectivity index, Olbas® might be suitable for topical treatment of herpetic infections.
No References for this article.
No Supplementary Data.
No Article Media
No Metrics

Document Type: Research Article

Publication date: August 1, 2013

More about this publication?
  • Pharmazie is a leading journal in the field of pharmaceutical sciences. As a peer-reviewed scientific journal, Pharmazie is regularly indexed in the relevant databases like Web of science, Journal Citation Reports and many others. The journal is open for submissions from the whole spectrum of pharnaceutical sciences including Pharmaceutical Chemistry, Experimental and Clinical Pharmacology, Drug Analysis, Pharmaceutics, Pharmaceutical Biology, Clinical Pharmacy etc.
  • Information for Authors
  • Submit a Paper
  • Subscribe to this Title
  • Ingenta Connect is not responsible for the content or availability of external websites
  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more