Effects of selective alpha 2-adrenoreceptor stimulation on capsaicin-evoked substance P release from primary cultured dorsal root ganglion neurons
Administration of clonidine could decrease VR1 mRNA expression but not SP mRNA. Administration of the selective alpha2 adrenoreceptor antagonist yohimbine did not have these effects. The inhibitory role of the selective alpha2 adrenoreceptor agonist clonidine on capsaicin-evoked SP release may be through decreasing VR1 mRNA levels then reducing the sensitivity of nociceptors to capsaicin. The data provided in the present study suggest that adrenergic modulation on primary sensory neurons by an alpha2 adrenoreceptor agonist may contribute to the analgesic effects in neurogenic inflammation.
Document Type: Research Article
Affiliations: 1: Department of Anatomy, Shandong University School of Medicine, Jinan, China 2: Tianjin Lung Cancer Institute, Tianjin Medical University General Hospital, Tianjin, China 3: Department of Nephrology, Shandong University Qilu Hospital, Jinan, China 4: Department of Histology and Embryology, Binzhou Medical University, 522 Huang He San Road, Binzhou, 256603, China, Email: [email protected] 5: Department of Anatomy, Shandong University School of Medicine, 44 Wenhua Xi Road, Jinan, 250012, China, Email: [email protected]
Publication date: 01 March 2010
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