Skip to main content
padlock icon - secure page this page is secure

Open Access The synthesis of phosphor ethers: who was Franz Anton Voegeli?

Download Article:
 Download
(PDF 488.7 kb)
 
The synthesis of the first organophosphate cholinesterase inhibitor (tetraethyl pyrophosphate, TEPP) is credited to the French organic chemist Philippe de Clermont (1831–1921) and to the Russian chemist Wladimir P. Moshnin from Moscow, both working in the laboratories of Adolphe Wurtz in Paris. In his publications de Clermont describes however not only the TEPP synthesis but also that of the related compound triethyl phosphate (TEP). TEP was previously synthesized by the Swiss chemist Franz Anton Voegeli (1825–1874), working in the laboratory of Gustav Magnus in Berlin. While TEPP is a potent organophosphate cholinesterase inhibitor with an IC50 in the low nanomolar range, TEP has no anticholinesterase activity up to millimolar concentrations. Therefore de Clermont and Moschnin are indeed the fathers of the first organophosphate cholinesterase inhibitor (TEPP), but are not entitled to claim paternity of the first compound in the class of phosphoric acid esters (TEP), an honor which belongs to Franz Anton Voegeli.
No References for this article.
No Supplementary Data.
No Article Media
No Metrics

Document Type: Research Article

Affiliations: 1: Department of Pharmacology & Therapeutics, Faculty of Medicine and Health Sciences, United Arab Emirates University, Al-Ain, United Arab Emirates 2: Department of Cell Biology, College of Medicine, Florida International University, 11200 SW 8th Street, GL 495E, Miami, FL 33199, USA, Email: [email protected]

Publication date: 01 April 2009

More about this publication?
  • Pharmazie is a leading journal in the field of pharmaceutical sciences. As a peer-reviewed scientific journal, Pharmazie is regularly indexed in the relevant databases like Web of science, Journal Citation Reports and many others. The journal is open for submissions from the whole spectrum of pharnaceutical sciences including Pharmaceutical Chemistry, Experimental and Clinical Pharmacology, Drug Analysis, Pharmaceutics, Pharmaceutical Biology, Clinical Pharmacy etc.
  • Information for Authors
  • Submit a Paper
  • Subscribe to this Title
  • Ingenta Connect is not responsible for the content or availability of external websites
  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more