Is the alkaloid pipermethystine connected with the claimed liver toxicity of Kava products?
The pyridone alkaloid pipermethystine has been considered to be responsible for alleged hepatoxicity of Kava products. Investigation of a series of retain samples of finished products from the German market and self-produced extracts from root and stem material of Piper methysticum
clearly showed that pipermethystine (1) is absent from all root and retain samples and extracts, with a limit of quantification of 45 ppm. As a positive control, leaves of P. methysticum showed an amount of 0.2% of 1. Thus, if there is any hepatotoxicity, compound
1 should not be the responsible constituent in the case reports with ethanolic extracts produced in Germany.
Document Type: Research Article
Affiliations: 1: Institute of Pharmaceutical Biology and Phytochemistry, Westfälische Wilhelms-Universität, Münster, Germany 2: Herbresearch Germany, Tussenhausen-Mattsies, Germany 3: Institute of Pharmaceutical Biology and Phytochemistry, Westfälische Wilhelms-Universität, Hittorfstr. 56, Münster, D-48149, Germany, Email: [email protected]
Publication date: January 1, 2008
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