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Open Access Pigment epithelium-derived factor (PEDF): drug developmental challenges ahead for a budding anti-angiogenic

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One of the most potent anti-angiogenic biological discovered to date, pigment epithelium-derived factor (PEDF) is fast becoming an exciting and promising lead candidate. Recent studies have shown that even shortened versions of the protein can serve as therapeutic agents with similar activity as the parent molecule. The next obvious challenge is to find ways to deliver this molecule in vivo with enhanced pharmacodynamics and reduced toxicity. Several methods to achieve this are proposed.
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Document Type: Research Article

Affiliations: 1: Departments of Orthopaedics and Surgery, University of Melbourne, St. Vincent’s Hospital, P.O. Box 2900, Fitzroy, Melbourne, 3065, Australia, Email: [email protected] 2: Departments of Orthopaedics and Surgery, University of Melbourne, St. Vincent’s Hospital, Melbourne, Australia 3: Bone and Soft Tissue Sarcoma Service, Peter MacCallum Cancer Institute, Melbourne, Australia

Publication date: January 1, 2008

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  • Pharmazie is a leading journal in the field of pharmaceutical sciences. As a peer-reviewed scientific journal, Pharmazie is regularly indexed in the relevant databases like Web of science, Journal Citation Reports and many others. The journal is open for submissions from the whole spectrum of pharnaceutical sciences including Pharmaceutical Chemistry, Experimental and Clinical Pharmacology, Drug Analysis, Pharmaceutics, Pharmaceutical Biology, Clinical Pharmacy etc.
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