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Open Access Determination of (–)-demecolcine and (–)-colchicine content in selected Jordanian Colchicum species

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In our continuing attempt to investigate Jordanian Colchicum species as a potential and viable source of colchicinoids; the distributions of the most interesting colchicinoid alkaloids (–)-demecolcine and (–)-colchicine in different plant parts of wildly growing C. crocifolium Boiss., C. ritchii R. Br., and C. triphyllum Kunze, were analyzed. The method is based on the use of external reference standards and a reversed-phase gradient HPLC. While (–)-colchicine was found in all plant parts of the three investigated Colchicum species, (–)-demecolcine was not detected in the leaves and daughter corms of C. triphyllum, the corms of C. crocifolium, and the flowers, stems, and mother and daughter corms of C. ritchii. C. triphyllum was found to be the highest in total (–)-colchicine content of 0.10% (wt/wt), while C. crocifolium was the highest in total (–)-demecolcine content of 0.09% (wt/wt). During flowering, leaves and corms in C. crocifolium, and leaves and stems in C. ritchii are the main storages of (–)-colchicine. (–)-Colchicine showed a homogenous distribution in all plant parts (stems, leaves, and mother and daughter corms) of C. triphyllum of 0.10% (wt/wt). Regarding (–)-demecolcine, stems and leaves of C. crocifolium, stems of C. triphyllum, and leaves of C. ritchii are the main storages. This work reports for the first time the presence of (–)-colchicine and (–)-demecolcine in C. crocifolium.
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Document Type: Research Article

Affiliations: 1: Department of Medicinal Chemistry and Pharmacognosy, Faculty of Pharmacy, P.O. Box 3030, Irbid, 22110, Jordan, Email: [email protected] 2: Pharmaceutical Research Center, Jordan University of Science and Technology, Irbid, Land 3: Department of Pharmaceutical Sciences, Faculty of Pharmacy, University of Jordan, Amman, Jordan

Publication date: October 1, 2007

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  • Pharmazie is a leading journal in the field of pharmaceutical sciences. As a peer-reviewed scientific journal, Pharmazie is regularly indexed in the relevant databases like Web of science, Journal Citation Reports and many others. The journal is open for submissions from the whole spectrum of pharnaceutical sciences including Pharmaceutical Chemistry, Experimental and Clinical Pharmacology, Drug Analysis, Pharmaceutics, Pharmaceutical Biology, Clinical Pharmacy etc.
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