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Open Access Anti-diabetic effect of Murraya koenigii leaves on streptozotocin induced diabetic rats

The present study was aimed to evaluate the anti-hyperglycemic efficacy of Murraya koenigii in STZ-induced diabetic rats. Oral administration of ethanolic extract of M. koenigii at a dose of 200 mg/kg/b.w./day for a period of 30 days significantly decreased the levels of blood glucose, glycosylated hemoglobin, urea, uric acid and creatinine in diabetic treated group of animals. Determination of plasma insulin level revealed the insulin stimulatory effect of the extract. The results suggest that M. koenigii possesses statistically significant hypoglycemic potential in STZ-induced diabetic rats. The M. koenigii extract appeared to be more effective than glibenclamide, a known antidiabetic drug.

Document Type: Research Article

Affiliations: 1: Department of Biochemistry and Molecular Biology, University of Madras, Chennai, Tamil Nadu, India 2: Department of Biochemistry and Molecular Biology, University of Madras, Chennai, Tamil Nadu, 600 025, India, Email: [email protected]

Publication date: October 1, 2006

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  • Pharmazie is a leading journal in the field of pharmaceutical sciences. As a peer-reviewed scientific journal, Pharmazie is regularly indexed in the relevant databases like Web of science, Journal Citation Reports and many others. The journal is open for submissions from the whole spectrum of pharnaceutical sciences including Pharmaceutical Chemistry, Experimental and Clinical Pharmacology, Drug Analysis, Pharmaceutics, Pharmaceutical Biology, Clinical Pharmacy etc.
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