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Open Access Toxicological mechanisms of Aconitum alkaloids

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The toxic effects of Aconitum alkaloids are known to affect mainly the central nervous system, heart and muscle tissues. Their toxicological mechanisms may involve interaction with voltage-dependent Na+ channels, modulation of neurotransmitter release and related receptors, promotion of lipid peroxidation and induction of cell apoptosis in heart, liver or other organs. Of them, the mechanism of interaction with voltage-dependent Na+ channels is quite well known, but the other factors are still unclear, and need to be further studied. This review focuses on the toxicological mechanisms of Aconitum alkaloids.
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Document Type: Research Article

Affiliations: 1: Medicine School and Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing, People's Republic of China 2: Beijing University of Chinese Medicine, Beijing, People's Republic of China 3: Medicine School and Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing, 100084, People's Republic of China, Email: [email protected]

Publication date: 01 September 2006

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  • Pharmazie is a leading journal in the field of pharmaceutical sciences. As a peer-reviewed scientific journal, Pharmazie is regularly indexed in the relevant databases like Web of science, Journal Citation Reports and many others. The journal is open for submissions from the whole spectrum of pharnaceutical sciences including Pharmaceutical Chemistry, Experimental and Clinical Pharmacology, Drug Analysis, Pharmaceutics, Pharmaceutical Biology, Clinical Pharmacy etc.
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