Topical delivery of retinyl ascorbate co-drug: 6. Determination of toxic dose and antioxidant activity in cultured human epidermal keratinocytes
The maximum effective dose of retinyl ascorbate and its potential therapeutic benefits against induced oxidative damage were assessed in vitro using cultured human epidermal keratinocytes. RA-AsA exhibited toxic effects at concentrations >6 μM. The findings indicate to
the potency of RA-AsA as free radical scavenger and cell proliferation regulator.
Document Type: Short Communication
Affiliations: 1: Welsh School of Pharmacy, Cardiff University, Cardiff, UK 2: Welsh School of Pharmacy, Cardiff University, Strasse, Cardiff, CF10 3XF, UK, Email: [email protected]
Publication date: October 1, 2005
- Pharmazie is a leading journal in the field of pharmaceutical sciences. As a peer-reviewed scientific journal, Pharmazie is regularly indexed in the relevant databases like Web of science, Journal Citation Reports and many others. The journal is open for submissions from the whole spectrum of pharnaceutical sciences including Pharmaceutical Chemistry, Experimental and Clinical Pharmacology, Drug Analysis, Pharmaceutics, Pharmaceutical Biology, Clinical Pharmacy etc.
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