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Open Access HPLC determination of telmisartan in human plasma and its application to a pharmacokinetic study

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A sensitive, simple, and accurate HPLC method was developed for the assay of telmisartan in human plasma. Using naproxen as internal standard, the assay involved liquid-liquid extraction of the compound from acidified plasma into organic solvent and reversed-phase chromatography with fluorescence detection. The assay was shown to be linear from 0.5 to 1000 ng/mL. In 24 healthy volunteers, the plasma concentrations of the drug were determined after a single oral dose of 160 mg.
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Document Type: Research Article

Affiliations: 1: Clinical pharmacy laboratory, Hua Shan Hospital, Fudan University, Shanghai, P.R. China 2: Clinical pharmacy laboratory, Hua Shan Hospital, Fudan University, Shanghai, 20040, P.R. China, Email: [email protected]

Publication date: June 1, 2005

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  • Pharmazie is a leading journal in the field of pharmaceutical sciences. As a peer-reviewed scientific journal, Pharmazie is regularly indexed in the relevant databases like Web of science, Journal Citation Reports and many others. The journal is open for submissions from the whole spectrum of pharnaceutical sciences including Pharmaceutical Chemistry, Experimental and Clinical Pharmacology, Drug Analysis, Pharmaceutics, Pharmaceutical Biology, Clinical Pharmacy etc.
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