@article {Gholap:2004:0031-7144:876,
title = "Hypoglycaemic effects of some plant extracts are possibly mediated through inhibition in corticosteroid concentration",
journal = "Die Pharmazie - An International Journal of Pharmaceutical Sciences",
parent_itemid = "infobike://govi/pharmaz",
publishercode ="govi",
year = "2004",
volume = "59",
number = "11",
publication date ="2004-11-01T00:00:00",
pages = "876-878",
itemtype = "ARTICLE",
issn = "0031-7144",
url = "https://www.ingentaconnect.com/content/govi/pharmaz/2004/00000059/00000011/art00014",
author = "Gholap, S. and Kar, A.",
abstract = "To unravel the possible mechanism of glucose lowering activity, effects of ten different plant extracts in the regulation of serum cortisol and glucose concentrations were evaluated in male mice. While the extracts of Inula racemosa, Boerhaavia diffusa and Ocimum sanctum
decreased the serum concentration of both cortisol and glucose, Aegle marmelos, Azadirachta indica and Gymnema sylvestre extracts could exhibit hypoglycaemic activity without altering the serum cortisol concentration. It appears that the hypoglycaemic effects of former three
plant extracts are mediated through their cortisol inhibiting potency, whereas the mechanism for other plant extracts could be different. Lipid-peroxidation was not enhanced by any of the plant extracts (some were in fact, antiperoxidative in nature). As I. racemosa, B. diffusa
and O. sanctum exhibited antiperoxidative, hypoglycaemic and cortisol lowering activities, it is suggested that these three plant extracts may potentially regulate corticosteroid induced diabetes mellitus.",
}