Skip to main content
padlock icon - secure page this page is secure

Open Access Cytotoxic activity of methanol extracts from Basidiomycete mushrooms on murine cancer cell lines

Download Article:
 Download
(PDF 90.5 kb)
 
Crude methanol extracts of 58 mushroom species were screened for their cytotoxic activities against two murine cancer cell lines, L1210 and 3LL, using the tetrazolium assay. A majority of extracts (74%) exhibited IC50 > 100 μg/ml against both cell lines. A most marked activity against one of the cell lines was noted for nine species (14% of the tested species). While Amanitales and Russulales tested were not found active, Polyporales and Boletales gave better results. Four species exhibited a significant cytotoxic activity (IC50 ≤ 20 μg/ml) against at least one of the two murine cancer cell lines (Ganoderma lucidum, Meripilus giganteus, Suillus granulatus, S. luteus). The last one had never been investigated for its cytotoxic compounds before.
No References for this article.
No Supplementary Data.
No Article Media
No Metrics

Document Type: Research Article

Affiliations: 1: Laboratoire de Pharmacognosie et de Mycologie. UPRES 2234 “Synthèse et extraction de molécules à visée thérapeutique”, 2 Avenue du Professeur Léon Bernard, Rennes, 35043, France, Email: [email protected] 2: Laboratoire de Pharmacognosie et de Mycologie. UPRES 2234 “Synthèse et extraction de molécules à visée thérapeutique”, Rennes, France

Publication date: 01 April 2004

More about this publication?
  • Pharmazie is a leading journal in the field of pharmaceutical sciences. As a peer-reviewed scientific journal, Pharmazie is regularly indexed in the relevant databases like Web of science, Journal Citation Reports and many others. The journal is open for submissions from the whole spectrum of pharnaceutical sciences including Pharmaceutical Chemistry, Experimental and Clinical Pharmacology, Drug Analysis, Pharmaceutics, Pharmaceutical Biology, Clinical Pharmacy etc.
  • Information for Authors
  • Submit a Paper
  • Subscribe to this Title
  • Ingenta Connect is not responsible for the content or availability of external websites
  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more