@article {Souza:2003:0031-7144:582,
title = "Evaluation of anti-inflammatory activity of essential oils from two Asteraceae species",
journal = "Die Pharmazie - An International Journal of Pharmaceutical Sciences",
parent_itemid = "infobike://govi/pharmaz",
publishercode ="govi",
year = "2003",
volume = "58",
number = "8",
publication date ="2003-08-01T00:00:00",
pages = "582-586",
itemtype = "ARTICLE",
issn = "0031-7144",
url = "https://www.ingentaconnect.com/content/govi/pharmaz/2003/00000058/00000008/art00014",
author = "Souza, M. C. and Siani, A. C. and Ramos, M. F. S. and Ramos, M. F. S. and Menezes-de-Lima Jr, O. and Henriques, M. G. M. O.",
abstract = "The essential oils from two Asteraceae species, Porophyllum ruderale (PR) and Conyza bonariensis (CB) were screened for anti-inflammatory activity in the mouse model of pleurisy induced by zymosan (500 g/cavity) and lipopolysaccharide (LPS) (250 ng/cavity). The main
monoterpene constituents of each oil, -myrcene (in PR) and limonene (in CB), were tested in the LPS-induced pleurisy model and assayed also for immunoregulatory activity by measurement of the inhibition of NO and production of the cytokines, -interferon and IL-4. The oils, when
administered orally, were able to inhibit the LPS-induced inflammation including cell migration; with a similar effect being observed for pure limonene. Pure -myrcene and limonene were also effective in inhibiting production of nitric oxide at doses below the cytotoxicity of these monoterpenes.
A significant inhibition of -interferon and IL-4 production by limonene and -myrcene was also observed.",
}