Skip to main content
padlock icon - secure page this page is secure

Open Access Evaluation of anti-inflammatory activity of essential oils from two Asteraceae species

Download Article:
 Download
(PDF 168.6 kb)
 
The essential oils from two Asteraceae species, Porophyllum ruderale (PR) and Conyza bonariensis (CB) were screened for anti-inflammatory activity in the mouse model of pleurisy induced by zymosan (500 μg/cavity) and lipopolysaccharide (LPS) (250 ng/cavity). The main monoterpene constituents of each oil, β-myrcene (in PR) and limonene (in CB), were tested in the LPS-induced pleurisy model and assayed also for immunoregulatory activity by measurement of the inhibition of NO and production of the cytokines, γ-interferon and IL-4. The oils, when administered orally, were able to inhibit the LPS-induced inflammation including cell migration; with a similar effect being observed for pure limonene. Pure β-myrcene and limonene were also effective in inhibiting production of nitric oxide at doses below the cytotoxicity of these monoterpenes. A significant inhibition of γ-interferon and IL-4 production by limonene and β-myrcene was also observed.
No References for this article.
No Supplementary Data.
No Article Media
No Metrics

Document Type: Research Article

Affiliations: 1: Laboratório de Química de Produtos Naturais e Farmacologia Aplicada, Instituto de Tecnologia em Fármacos, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil 2: Laboratório de Química de Produtos Naturais e Farmacologia Aplicada, Instituto de Tecnologia em Fármacos, Universidade Federal do Rio de Janeiro, Rio Sizenando Nabuco 100, Rio de Janeiro, 21041-250, Brazil, Email: [email protected] 3: Fundação Oswaldo Cruz and Centro de Ciências da Saúde, Faculdade de Farmácia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil

Publication date: 01 August 2003

More about this publication?
  • Pharmazie is a leading journal in the field of pharmaceutical sciences. As a peer-reviewed scientific journal, Pharmazie is regularly indexed in the relevant databases like Web of science, Journal Citation Reports and many others. The journal is open for submissions from the whole spectrum of pharnaceutical sciences including Pharmaceutical Chemistry, Experimental and Clinical Pharmacology, Drug Analysis, Pharmaceutics, Pharmaceutical Biology, Clinical Pharmacy etc.
  • Information for Authors
  • Submit a Paper
  • Subscribe to this Title
  • Ingenta Connect is not responsible for the content or availability of external websites
  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more