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Open Access Hawthorn extracts inhibit LDL oxidation

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Polyphenol-rich diet decreases cardiovascular risk. LDL oxidation is the primary event in atherosclerosis plaque formation and antioxidants such as polyphenols were shown to inhibit LDL oxidation and atherosclerosis development. Hawthorn (Crataegus) and derived pharmaceuticals are rich in polyphenols and already prescribed to treat moderate heart failure, nervousness and sleep disorders. Extracts either from fresh plant parts (flower buds, flowers, young leaves or green fruits) or from dried pharmaceutical parts (flowers and flowering tops) were previously shown to be effective inhibitors of lipoperoxidation and scavengers of oxygen species. In this study, the capacity of total and ethyl-acetate extracts from dried pharmaceutical flowers, tops and fruits to inhibit Cu2+-induced LDL oxidation was tested. This capacity was positively linked to their content in total polyphenols, proanthocyanidins (global and oligomeric forms), as well as to their content in two individual phenolics: a flavanol, the dimeric procyanidin B2 and a flavonol glycoside, hyperoside. Flavanol-type phenolics showed to be higher active than the majority of the flavonoids tested in inhibiting Cu2+-induced LDL peroxidation. This study suggests that hawthorn could be a source of polyphenols able to inhibit LDL oxidation.
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Document Type: Research Article

Affiliations: 1: Laboratoire de Pharmacognosie, Faculté de Pharmacie, Lille, France 2: Laboratoire de Physiologie Cellulaire et Morphogénèse Végétales, UFR de Biologie, Université des Sciences & Technologies de Lille, Villeneuve d'Ascq, France 3: Département d'Athérosclérose, Institut Pasteur, Lille, France 4: Laboratoire de Physiologie Cellulaire et Morphogénèse Végétales, UFR de Biologie, Université des Sciences & Technologies de Lille, Strasse, Villeneuve d'Ascq, Postleitzahl, France, Telefon, Fax, 5: Laboratoire de Pharmacognosie, Faculté de Pharmacie, BP 83, Lille, F-59006, France, Email: [email protected]

Publication date: August 1, 2003

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  • Pharmazie is a leading journal in the field of pharmaceutical sciences. As a peer-reviewed scientific journal, Pharmazie is regularly indexed in the relevant databases like Web of science, Journal Citation Reports and many others. The journal is open for submissions from the whole spectrum of pharnaceutical sciences including Pharmaceutical Chemistry, Experimental and Clinical Pharmacology, Drug Analysis, Pharmaceutics, Pharmaceutical Biology, Clinical Pharmacy etc.
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