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Sanitisation with vapour phase hydrogen peroxide – practical cycle development and future improvements

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Vapour phase hydrogen peroxide (VPHP) has been in use as a sanitising agent, particularly for isolators, for over 20 years. During this time the process has gained a reputation for lengthy and complex cycle development, and for some unreliability. These problems stem from two points:

a. Lack of understanding how the vapour phase hydrogen peroxide process actually works.

b. Lack of consistency in the biological indicators used to challenge the process.

This paper starts by explaining how the vapour phase hydrogen peroxide rapid sporicidal process works and continues with a description of the present methods of cycle development. The paper continues with some suggestions as to how cycle development can be speeded up considerably and introduces enzyme indicators (EIs) as a recent development to add to chemical indicators (CIs) and possibly replace biological indicators (BIs). The paper offers practical solutions to both the problems mentioned above, based on long experience with the design, construction and validation of vapour phase hydrogen peroxide generators.
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Document Type: Research Article

Publication date: January 1, 2017

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