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Open Access Ameliorative and antidyslipidemic potentials of aqueous leaf extract of Gongronema latifolium in CCl4 carbon tetrachloride-induced oxidative stress rats

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Objective: To investigate the effect of leaf aqueous extract from Gongronema latifolium (G. latifolium) on CCl4 induced-oxidative stress in Wistar rat. This effect was assessed by measuring liver marker enzymes activity, analyzing the antioxidant parameters, lipid profile estimation and lipid peroxidation by-product following CCl4 induced-oxidative stress. Methods: Milled G. latifolium leaves were subjected to aqueous extraction and the filtrate was evaporated between 40–60 °C under reduced pressure and a calculated volume of the leaf extract was administered at a dose of 500 mg/kg body weight. Thirty-five rats were grouped into seven groups of 5 animals each namely; control and experimental groups. The experimental groups were treated with 2.0 mL/kg body weight CCl4, 25 mg/kg body weight/ day silymarin (a standard hepatoprotective antioxidant), 500 mg/kg body weight aqueous extract of G. latifolium leaves were administered to the CCl4 treated rats for 21 days. Results: Administration of the extract and silymarin increase significantly (P < 0.05) in liver marker enzyme (aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase and gamma-glutamyl transpeptidase) activities in serum, liver and kidney in the treated groups when compared with untreated groups. The antioxidant parameters (catalase, peroxidase and glutathione S-transferase) were significantly elevated (P < 0.05) in animals treated with the extract and silymarin in comparison with untreated groups. CCl4 induced oxidative stress mediated variations in total cholesterol, triacylglycerides, high-density lipoprotein cholesterol, low density lipoprotein cholesterol and very low-density lipoprotein cholesterol were restored significantly (P < 0.05) by the extract. Conclusions: The result obtained from this study indicated the antioxidant and antidyslipidemic potentials of the aqueous extract of G. latifolium leaves.
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Document Type: Research Article

Affiliations: 1: Department of Biological Science, College of Natural Science, Al-Hikmah University, Ilorin, P. M. B. 1601, Kwara State, Nigeria 2: Department of Biosciences and Biotechnology (Biochemistry Unit), Kwara State University, Malete, P.M.B. 1530, Ilorin, Nigeria 3: Biotechnology and Genetic Engineering Advanced Laboratory, Sheda Science and Technology Complex, Sheda, Abuja

Publication date: January 1, 2016

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