Partridge embryo pathology in relation to gentamicin-induced lesions
Objective: To determine the macroscopic and microscopic lesions of various dosages of
gentamicin in the partridge embryo.
Methods: Fertile chukar partridge eggs were allocated into four groups. Group 1: salineinjected
group whose individuals were administered by sterile physiological saline solution
of 0.2 mL/egg inserted into yolk sac. Groups 2, 3 and 4 whose individuals were similarly
administered by gentamicin sulfate at a dosage of 80 mg/kg egg-weight once, twice and three
times, respectively.
Results: Results showed that the embryos were congested and stunted in the gentamicininjected
groups. Defects in feet, wings and feather development were accompanied by
microscopic lesions in brain, meninges, heart, lungs, liver and kidneys. Histopathological
lesions were noticed as edema, undeveloped tissues, necrosis and degeneration in the affected
organs.
Conclusions: Based on acquired results, it is concluded that gentamicin at above-described
dosages causes toxicopathological effects to the partridge embryo in a dose dependent manner.
Document Type: Research Article
Affiliations: 1: Department of Avian Medicine, School of Veterinary Medicine, Shahid Bahonar University of Kerman, Kerman, Iran 2: Diagnostic Laboratory Sciences and Technology Research Center, Center of Comparative and Experimental Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
Publication date: 01 January 2016
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