The accuracy of newly proposed warning signs in the third edition of Malaysian guideline on the management of dengue infection in adult
Objective: To evaluate the accuracy of persistent vomiting and persistent diarrhoea proposed in
the Malaysian dengue guideline.
Methods: The eligibility criteria were dengue patients with vomiting or/and diarrhoea at the
earliest day of illness without other warning signs. Vomiting and diarrhoea categorised by three
or more episodes over 24 h were considered as warning signs. Sensitivity, specificity, positive
predictive value and negative predictive value were calculated.
Results: There were a total of 479 patients, of whom 36 (7.5%) got severe dengue and 443
(92.5%) got dengue with warning signs. The overall accuracy ranged from 33.3% to 72.7%
for sensitivity, 28.8% to 56.5% for specificity, 1.8% to 14.5% for positive predictive value and
88.5% to 96.3% for negative predictive value. There were 16 false negative.
Conclusions: The newly proposed warning signs in the third edition of Malaysian dengue
guideline may not be effective in predicting severe dengue.
Document Type: Research Article
Affiliations: Department of Population Medicine, Faculty of Medicine and Health Sciences, Universiti Tunku Abdul Rahman, Jalan Sungai Long, Bandar Sungai Long, Cheras 43000 Kajang, Selangor, Malaysia
Publication date: 01 January 2016
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