Marine soft corals as source of lead compounds for anti-inflammatories
Marine soft corals are known to produce a wide array of secondary metabolites, particularly
diterpenoids and steroids, and often characterized by uncommon structural features and potent
bioactivities. The remarkable abundance and diversity of bioactive small molecule which have
been isolated from soft corals have made these organisms an important source of new drug
candidates for human diseases, particularly for their anti-inflammatory activity. In this paper,
the authors reported anti-inflammatory marine natural products isolated from diverse species of
soft corals determined in vitro by their inhibition of lipopolysaccharide-induced expression of
inducible NO synthase and cyclooxygenase-2 in murine macrophage cells (RAW 264.7).
Document Type: Research Article
Affiliations: Research Center for Oceanography, the Indonesian Institute of Sciences (LIPI), Jl. Pasir Putih I, Ancol Timur, Jakarta, 14430, Indonesia
Publication date: 01 January 2016
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