Direct and indirect antimicrobial effects of α-mangostin on pathogenic microorganisms
Objective: To test direct and indirect antimicrobial properties of α-mangostin towards a number
of bacteria and fungi.
Methods: The experiment was carried out using broth microdilution and checkerboards methods.
Activity of α-mangostin paired with an antibiotic was studied by calculating its fractional
inhibitory concentration (FIC).
Results: The activity of all four bacteria towards ampicillin, penicillin G, streptomycin and
tetracycline showed no interaction with the combination with α-mangostin where the FIC indexes
were between the range of 0.54. Activity of doxycycline on Pseudomonas aeruginosa fell
into other set of range, FICindex≥4 which is an antagonism.
Conclusions: The FIC index is far away in the range. The coupled antibiotic and α-mangostin is
considered synergy in action if it lies in FICindex≤0.5 and it was found that the isolated compound,
α-mangostin revealed very low synergistic antimicrobial effects when coupled with antibiotics.
Document Type: Research Article
Affiliations: 1: Department of Biomedical Science, Faculty of Science, International Islamic University Malaysia, 25200 Kuantan, Pahang, Malaysia 2: Department of Pharmaceutical Technology, Faculty of Pharmacy, International Islamic University Malaysia, 25200 Kuantan, Pahang, Malaysia 3: Department of Chemistry, Faculty of Science, International Islamic University Malaysia, 25200 Kuantan, Pahang, Malaysia 4: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, International Islamic University Malaysia, 25200 Kuantan, Pahang, Malaysia
Publication date: 01 January 2014
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