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Publisher: Directory of Open Access Journals

Volume 6, Number 5, 2016

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Open Access An update on the role of intestinal cytochrome P450 enzymes in drug disposition
pp. 374-383(10)
Authors: Fang Xie; Xinxin Ding; Qing-Yu Zhang

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Open Access Isoniazid metabolism and hepatotoxicity
pp. 384-392(9)
Authors: Pengcheng Wang; Komal Pradhan; Xiao-bo Zhong; Xiaochao Ma

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Open Access Fatty liver diseases, bile acids, and FXR
pp. 409-412(4)
Authors: Yan Zhu; Hongxia Liu; Min Zhang; Grace L. Guo

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Open Access Insights into CYP2B6-mediated drug–drug interactions
pp. 413-425(13)
Authors: William D. Hedrich; Hazem E. Hassan; Hongbing Wang

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Open Access PBPK modeling and simulation in drug research and development
pp. 430-440(11)
Authors: Xiaomei Zhuang; Chuang Lu

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Open Access PXR variants: the impact on drug metabolism and therapeutic responses
pp. 441-449(9)
Authors: C. Trent Brewer; Taosheng Chen

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Open Access Role of farnesoid X receptor in establishment of ontogeny of phase-I drug metabolizing enzyme genes in mouse liver
pp. 453-459(7)
Authors: Lai Peng; Stephanie Piekos; Grace L. Guo; Xiao-bo Zhong

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Open Access Tissue distribution and tumor uptake of folate receptor–targeted epothilone folate conjugate, BMS-753493, in CD2F1 mice after systemic administration
pp. 460-467(8)
Authors: Hong Shen; Lifei Wang; Weiqi Chen; Krista Menard; Yang Hong; Yuan Tian; Samuel J. Bonacorsi; W. Griffith Humphreys; Francis Y. Lee; Jinping Gan

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Open Access Effect of age on the pharmacokinetics of polymorphic nimodipine in rats after oral administration
pp. 468-474(7)
Authors: Wenli Liu; Xiaona Wang; Ruilian Chen; Kaixuan Zhang; Yao Li; Yi Li; Duanyun Si; Junbo Gong; Dianshu Yin; Yongli Wang; Zhenping Wei; Mingshi Yang

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Open Access Development of a mechanism-based pharmacokinetic/pharmacodynamic model to characterize the thermoregulatory effects of serotonergic drugs in mice
pp. 492-503(12)
Authors: Xi-Ling Jiang; Hong-Wu Shen; Donald E. Mager; Stephan Schmidt; Ai-Ming Yu

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Open Access 17β-Estradiol up-regulates UDP-glucuronosyltransferase 1A9 expression via estrogen receptor α
pp. 504-509(6)
Authors: Sung-joon Cho; Miaoran Ning; Yanyan Zhang; Leah H. Rubin; Hyunyoung Jeong

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