Nourishing Yin and Promoting Blood Circulation of TCM to Treat Hemorheologic Disorder Induced by Diabetes Mellitus in Rats
Diabetes mellitus, DM, is commonly accompanied with various stages of hemorheologic disturbances that are the main causes of the development of chronic DM. In this study, simple Chinese material medica [yang-yin jiang-tang preparation (YYJT)] was given to alloxan-induced DM rats and analyzed to compare the changes of fasting blood glucose (FBG), fasting insulin (FINS), hemorheologic parameters and insulin-like growth factor II (IGF-II) before and after administration. The results suggested that YYJT can significantly downregulate FBG (P < 0.005), improve insulin resistance and beta-cell secretion (P < 0.05), decrease whole blood viscosity at low and high shear rates, gathering of blood index test (GIT) and fibrinogen (FIB) (P < 0.05), and enlarge the function of IGF-II (P < 0.05). We concluded that YYJT could prevent and treat hemorheologic disorder in DM rats by means of reducing glucose, improving insulin resistance and elevating IGF-II.
Document Type: Research Article
Affiliations: 1: Department of Basic Medicine, Zhejiang Chinese Medical University Binjiang, Hangzhou 310053, Zhejiang Province, China 2: Department of Endocrinology, Affiliated Hospital of Zhejiang Chinese Medical University Youdianlu, Hangzhou 310005, Zhejiang Province, China 3: Department of Laboratory, Affiliated Hospital of Zhejiang Chinese Medical University Youdianlu, Hangzhou 310005, Zhejiang Province, China
Publication date: 01 January 2007
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