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Open Access OPPORTUNITIES OF ANTI B-CELL THERAPY IN MULTIPLE SCLEROSIS

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Abstract. A new role of B-cells in pathogenesis of multiple sclerosis (MS), their relations with B-cells in
development of inflammation and probable mechanisms of advanced therapeutic intervention in order to reach B-cell depletion are subject to discussion in present article. Here we describe a clinical case of MS with a resistant clinical course, and results of anti B-cell treatment. To attain maximal clinical effect, a novel therapeutic regimen (a combination of rituximab and mitozantrone) was applied. Clinical, radiological and laboratory methods were used to substantiate the efficiency of treatment.

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Document Type: Research Article

Affiliations: 1: Ленинградская областная клиническая больница (ЛОКБ), Ленинградский областной центр рассеянного склероза, Санкт-Петербургский государственный медицинский университет им. академика И.П. Павлова 2: ФГУ «Центр сердца крови и эндокринологии им. В.А. Алмазова», Санкт-Петербург 3: Санкт-Петербургский государственный медицинский университет им. академика И.П. Павлова 4: Ленинградский областной центр рассеянного склероза, Ленинградская областная клиническая больница (ЛОКБ) 5: НМЦ по молекулярной медицине МЗиСР РФ на базе Санкт-Петербургского государственного медицинского университета им. академика. И.П. Павлова

Publication date: January 1, 2009

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