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Open Access Efeito da berinjela sobre os lípides plasmáticos, a peroxidação lipídica e a reversão da disfunção endotelial na hipercolesterolemia experimental Effect of eggplant on plasma lipid levels, lipidic peroxidation and reversion of endothelial dysfunction in experimental hypercholesterolemia

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OBJETIVO: Estudar o efeito do suco da berinjela sobre os lípides plasmáticos, o colesterol tecidual, a peroxidação lipídica das LDL nativas, oxidadas e da parede arterial e o relaxamento dependente do endotélio, em coelhos hipercolesterolêmicos. MÉTODOS: Coelhos foram separados em grupos controle (GC), hipercolesterolêmico (GH) e berinjela (GB), (n=10). Os animais do GC foram alimentados com ração normal, o GH e o GB com ração acrescentada de colesterol (0,5%) e gordura de babaçu (10%) durante 30 dias. Ao GB acrescentou-se suco de berinjela, nos últimos 15 dias do experimento. Os lípides plasmáticos foram medidos através de kits enzimáticos, a peroxidação lipídica pela dosagem do malondialdeído (MDA) e o relaxamento dependente do endotélio, por curvas de concentração efeito pela acetilcolina e nitroprussiato. RESULTADOS: O peso dos animais foi menor no GB em relação ao GC e GH (p<0,05). O colesterol total plasmático, as LDL e os triglicérides que se elevaram no GH, reduziram-se em 19%, 29% e 38%, respectivamente no GB (p<0,05). O colesterol tecidual foi menor no GB (50%) em relação ao GH (p<0,05). Nos animais do GB ocorreu redução significante do teor de MDA nas LDL nativas (56%) e oxidadas (22%), assim como na parede arterial (30%) (p<0,05). O relaxamento máximo dependente do endotélio, , elevou-se significantemente em 28% no GB em relação ao GH (p<0,05). CONCLUSÃO: O suco de berinjela administrado a coelhos hipercolesterolêmicos reduziu significantemente o peso corpóreo, o colesterol total, as LDL plasmáticas, os triglicérides, o colesterol tecidual, a peroxidação lipídica das LDL nativas, oxidadas e da parede arterial, assim como aumentou o relaxamento dependente do endotélio.
PURPOSE: To study the effect of egg plant on endothelium-dependent relaxation, and plasma lipids in hypercholesterolemic rabbits, and to assess influence of this plant on the malondialdehyde (MDA) content of LDL particles and the arterial wall. METHODS: Thirteen male rabbits were randomly assigned to control (C), hypercholesterolemic (H) and egg plant (E) treated groups (n=10 each). The H and E rabbits were fed a diet supplemented with cholesterol (0.5%) and coconut oil (10%) for 4 weeks. In addition, group E received 10mL of the fruit juice/day during the last 2 weeks.The animals were killed and the aorta removed to measure MDA content and the endothelium dependent relaxation responses. Total plasma cholesterol, VLDL, LDL, HDL and triglyceride levels were determined using commercial kits. MDA was quantified in native and oxidized LDL and in the arterial wall. RESULTS: After 4 weeks, the E group rabbits had a significantly lower weight , plasma cholesterol, LDL, triglyceride and aortic cholesterol contentthan group H(p<0.05). The MDA content that was significantly increased in the LDL particles and in the arterial wall of H rabbits was reduced in the E group (p<0.05). Endothelium-dependent relaxation were significantly higher in the E group compared H group rabbits (p<0.05). CONCLUSION: In hypercholesterolemic rabbits egg plant juice significantly reduced weight, plasma cholesterol levels, aortic cholesterol content and the MDA concentrations in native-oxidized LDL and in the arterial wall and increased the endothelium-dependent relaxations.
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Document Type: Research Article

Publication date: January 1, 1998

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