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Open Access Relationship between fibroblast growth factor 21 and thyroid stimulating hormone in healthy subjects without components of metabolic syndrome

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Objective: To determine the relationship between human fibroblast growth factor 21 (FGF21) and thyroid stimulating hormone (TSH) by testing the level of FGF21, lipid metabolism, and carbohydrate metabolism-related indices, as well as the level of TSH, among metabolic syndrome-free patients with normal physical examination results.

Methods: An enzyme-linked immunosorbent assay (ELISA) was used to test the levels of serum FGF21 and free fatty acids (FFA) in metabolic syndrome-free patients with normal physical examination results, and electrochemiluminescence (ECLIA) was used to measure TSH, thyroglobulin antibodies (TGAbs), and thyroid peroxidase antibody (TPOAb) levels.

Results: Three hundred fifty-six metabolic syndrome-free patients (116 males and 240 females; average age, 43±13 years) with normal physical examination results were enrolled. Among the patients with normal physical examination results, FGF21 had a weak relationship with obesity indices, such as the waist circumference (r=0.110, P=0.038), the waist-to-hip ratio (r=0.119, P=0.025), and the triglycerides level (TG; r=0.302, P=0.000), and a weak relationship with blood lipid levels, such as total cholesterol (TCHO; r=0.113, P=0.012) and low-density lipoprotein-cholesterol (LDL-C; r=0.175, P=0.001), but no relationship with TSH (r=‐0.023, P=0.666). In addition, the FGF21 levels in thyroid autoantibody-positive and -negative groups were not significantly different.

Conclusion: Among the metabolic syndrome-free patients with normal physical examination results, FGF21 has no apparent relationship with TSH or thyroid autoimmunity.

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Keywords: Autoimmunity; Free fatty acids (FFA); Human fibroblast growth factor 21 (FGF21); Thyroid stimulating hormone (TSH)

Document Type: Research Article

Publication date: September 1, 2014

More about this publication?
  • Family Medicine and Community Health (FMCH) is an open-access journal focusing on subjects that are common and relevant to family medicine/general practice and community health. The journal publishes relevant content across disciplines such as epidemiology, public health, social and preventive medicine, research and evidence based medicine, community health service, patient education and health promotion and health ethics. The journal has a specific focus on the management of chronic illness particularly diabetes, ischaemic heart disease, chronic heart failure, hypertension, bronchial asthma, chronic obstructive airways disease and common mental illness. FMCH is published by Compuscript on behalf of the Chinese General Practice Press

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