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Open Access Meta-analysis on the relevance of HLA-DRB1 gene polymorphisms in a Chinese population with pulmonary tuberculosis

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Objective: The current meta-analysis determined the relevance of HLA-DRB1 gene polymorphisms in a Chinese population with pulmonary tuberculosis.

Methods: The CBM, CNKI, and MEDLINE databases were retrieved by computers. Domestic and international documents involving studies on the relevance of HLA-DRB1 gene polymorphisms in a Chinese population with pulmonary tuberculosis were collected from the database until May 2013, and statistical analysis was performed on all of the eligible results with RevMan5.0 software.

Results: Eleven case-control studies were collected, including 1364 cases in the pulmonary tuberculosis group and 1496 cases in the control group.

The consolidated OR values and 95% confidence intervals of the case and control groups of HLA-DRB1 *04, HLA-DRB1 *15, and HLA-DRB1 *16 were 1.32 (1.09‐1.60), 1.40 (1.01‐1.93), and 1.36 (1.01‐1.83), respectively.

Conclusion: HLA-DRB1 *04, HLA-DRB1 *15, and HLA-DRB1 *16 may be susceptibility genes for pulmonary tuberculosis in a Chinese population.

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Keywords: HLA-DRB1 gene; Meta-analysis; Polymorphism; Pulmonary tuberculosis

Document Type: Research Article

Publication date: 01 June 2014

More about this publication?
  • Family Medicine and Community Health (FMCH) is an open-access journal focusing on subjects that are common and relevant to family medicine/general practice and community health. The journal publishes relevant content across disciplines such as epidemiology, public health, social and preventive medicine, research and evidence based medicine, community health service, patient education and health promotion and health ethics. The journal has a specific focus on the management of chronic illness particularly diabetes, ischaemic heart disease, chronic heart failure, hypertension, bronchial asthma, chronic obstructive airways disease and common mental illness. FMCH is published by Compuscript http://www.compuscript.com on behalf of the Chinese General Practice Press http://www.chinagp.net.

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