Skip to main content
padlock icon - secure page this page is secure

Open Access Calcium-Sensing Receptor of Immune Cells and Diseases

Download Article:
(PDF 603.2 kb)
Calcium-sensing receptor (CaSR), which was initially found in the parathyroid gland, is ubiquitously expressed and exerts specific functions in multiple cells, including immune cells. CaSR is functionally expressed on neutrophils, monocytes/macrophages, and T lymphocytes, but not B lymphocytes, and regulates cell functions, such as cytokine secretion, chemotaxis, phenotype switching, and ligand delivery. In these immune cells, CaSR is involved in the development of many diseases, such as sepsis, cryopyrin-associated periodic syndromes, rheumatism, myocardial infarction,diabetes, and peripheral artery disease. Since its discovery, it has been controversial whether CaSR is expressed and plays a role in immune cells. This article reviews current knowledge of the role of CaSR in immune cells.
No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Keywords: Calcium-sensing receptor; neutrophil; monocyte/macrophage; T lymphocyte; B lymphocyte

Affiliations: The First Affiliated Hospital of Harbin Medical University,

Appeared or available online: March 1, 2021

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more