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Open Access Dyssynchrony Induced by Ventricular Preexcitation: A Risk Factor for the Development of Dilated Cardiomyopathy

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Significant left ventricular dysfunction may arise in right-sided accessory pathways with ventricular preexcitation in the absence of recurrent or incessant tachycardia. This has just been realized and not enough attention has been paid to it. Methods: In the last 7 years, we identified 12 consecutive children with a diagnosis of ventricular preexcitation– induced dilated cardiomyopathy. This report describes the clinical and echocardiographic characteristics of the patients before and after ablation. Results: Dyssynchronous ventricular contraction was observed by M-mode echocardiography and two-dimensional strain analysis in all patients. The basal and middle segments of the interventricular septum became thin and moved similarly to an aneurysm, with typical bulging during the end of systole. The locations of the accessory pathways were the right-sided septum (n = 5) and the free wall (n = 7). Left ventricular synchrony was obtained shortly after ablation. The left ventricular function recovered to normal and the left ventricular end-diastolic diameter decreased gradually during follow-up. Conclusions: A causal relationship between ventricular preexcitation and the development of dilated cardiomyopathy is supported by the complete recovery of left ventricular function and reversed left ventricular remodeling after the loss of ventricular preexcitation. Preexcitation-related dyssynchrony was thought to be the crucial mechanism. Ventricular preexcitation–induced dilated cardiomyopathy is an indication for ablation with a good prognosis.
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Keywords: ; ventricular preexcitation; accessory pathway; Wolff-Parkinson-White syndrome; dyssynchrony; dilated cardiomyopathy

Affiliations: Beijing Anzhen Hospital

Appeared or available online: June 10, 2020

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