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Open Access Association of Serum Chemerin Levels with Coronary Artery Disease: Pathogenesis and Clinical Research

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Recent studies have revealed that chemerin plays an essential role in the development of cardiovascular diseases. Autopsy studies found a strong correlation between the secretion of chemerin in peripheral tissues and aortic and coronary atherosclerosis. Plasma chemerin is a marker of systemic inflammation and is associated with metabolic syndrome. Chemerin plays a vital role in vascular inflammation and atherogenesis. Plasma chemerin levels are increased in patients with dilated cardiomyopathy, and chemerin is associated with left ventricular dysfunction. In this review, we focus on chemerin expression, chemerin processing, its biological function, and its role in the diagnosis of cardiovascular diseases.
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Keywords: atherosclerosis; chemerin; heart failure; coronary artery disease; inflammation; metabolic syndrome

Affiliations: Adiyaman Education and Research Hospital, Turkey

Appeared or available online: April 9, 2020

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