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Open Access An Open Invitation to Join the International Brugada Electrocardiographic Indices Registry

Background: The Brugada Electrocardiographic Indices Registry is a comprehensive data registry composed of patients with Brugada patterns on the electrocardiogram (ECG). The aim is to test the hypotheses that (i) ECG indices combining both depolarization and repolarization abnormalities can better predict spontaneous ventricular arrhythmias than existing ECG markers in Brugada syndrome and (ii) that serial ECG measurements will provide additional information for risk stratification, especially in asymptomatic patients.

Methods: Patients with both Brugada pattern ECGs and Brugada syndrome are eligible for inclusion in this registry. Baseline characteristics and ECG variables reflecting depolarization and repolarization will be determined. The primary outcome is spontaneous ventricular tachycardia/ventricular fibrillation or sudden cardiac death. Secondary outcomes are inducible ventricular tachycardia/ventricular fibrillation and syncope.

Results: As of November 15, 2019, 39 investigators from 32 cities in 18 countries had joined this registry. As of December 15, 2019, 1383 cases had been enrolled.

Conclusions: The Brugada Electrocardiographic Indices Registry will evaluate the disease life course, risk factors, and prognosis in a large series of Brugada patients. It will therefore provide insights for improving risk stratification.

Keywords: BEIR consortium; Brugada syndrome; Sudden cardiac death; electrocardiogram indices; risk stratification

Document Type: Research Article

Affiliations: 1: Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, 300211 Tianjin, China 2: Laboratory of Cardiovascular Physiology, Li Ka Shing Institute of Health Sciences, Hong Kong Special Administrative Region, China 3: Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510000 Guangdong, China 4: Xiamen Cardiovascular Hospital, Xiamen University, Xiamen, 361000 Fujian, China 5: Department of Cardiology, Luoyang Central Hospital Affiliated to Zhengzhou University, Luoyang, 471009 Henan, China 6: Department of Cardiology, The First Affiliated Hospital of Xiamen University, Xiamen, 361000 Fujian, China 7: Department of Cardiology, The First People’s Hospital of Changzhou, Changzhou, 213000 Jiangsu, China 8: Department of Cardiology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, 200000 Shanghai, China 9: Guangdong General Hospital, No. 106 Zhongshan 2nd Road, Yuexiu District, Guangzhou, 510080 Guangdong, China 10: Arrhythmia Unit, Department of Cardiovascular Medicine, First Affiliated Hospital of Xi’an Jiaotong University, No. 277 Yanta West Road, Xi’an, 710000 Shaanxi, China 11: Department of Cardiology and Cardiovascular Research Institution, Renmin Hospital of Wuhan University, Wuhan, 430000 Hubei, China 12: School of Data Science, City University of Hong Kong, Hong Kong Special Administrative Region, China 13: Lankenau Institute for Medical Research, Wynnewood, PA 19096, USA 14: Department of Cardiology, The First Affiliated Hospital of Dalian Medical University, Dalian, 116000 Liaoning, China

Publication date: January 1, 2020

More about this publication?
  • Cardiovascular Innovations and Applications (CVIA) publishes focused articles and original clinical research that explore novel developments in cardiovascular disease, effective control and rehabilitation in cardiovascular disease, and promote cardiovascular innovations and applications for the betterment of public health globally. The journal publishes basic research that has clinical applicability in order to promote timely communication of the latest insights relating to coronary artery disease, heart failure, hypertension, cardiac arrhythmia, prevention of cardiovascular disease with a heavy emphasis on risk factor modification. Cardiovascular Innovations and Applications is the official journal of the Great Wall International Congress of Cardiology (GW-ICC). It aims to continue the work of the GW-ICC by providing a global scientific communication platform for cardiologists that bridges East and West.

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