The Relationship Between Mean Platelet Volume and In-Hospital Mortality in Geriatric Patients with ST Segment Elevation Myocardial Infarction Who Underwent Primary Percutaneous Coronary Intervention

Objective: We planned to investigate the effect of mean platelet volume (MPV) on in-hospital mortality and coronary risk factors in geriatric patients with ST segment elevation myocardial infarction (STEMI) who underwent primary percutaneous coronary intervention (PCI).

Methods: We enrolled 194 consecutive STEMI patients. The study population was divided into two groups on the basis of admission MPVs. The high-MPV group (n=49) included patients in the highest tertile (>8.9 fL), and the low-MPV group (n=145) included patients with a value in the lower two tertiles (≤8.9 fL). Clinical characteristics, in-hospital mortality, cardiovascular risk factors, and outcomes of primary PCI were analyzed.

Results: The patients in the high-MPV group were older, more of them had three-vessel disease, and they had higher in-hospital mortality. Patients with in-hospital death were older, had higher Gensini score, creatinine concentration, and MPV, and had lower HDL cholesterol concentration. MPV, age, HDL cholesterol concentration, creatinine concentration, and Gensini score were found to be independent predictors of in-hospital death.

Conclusion: These results suggest that high admission MPV levels are associated with increased in-hospital mortality in geriatric patients with STEMI undergoing primary PCI.