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Open Access Practical Clinical Application of Cardiac Computed Tomography‐Derived Fractional Flow Reserve

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This article is Open Access under the terms of the Creative Commons CC BY-NC licence.

In the past decade, advances in coronary computed tomography angiography (CTA) technology have resulted in high sensitivity and negative predictive value in detecting coronary artery disease (CAD) compared with invasive coronary angiography, particularly for patients with mild or severe stenosis. However, anatomical evaluation of CAD by CTA has modest specificity for patients with intermediate-grade stenoses. The recent development of the use of cardiac computed tomography‐derived fractional flow reserve (FFR-CT) seeks to address this gap as a proposed method of functional assessment of CAD by CTA. In this article we aim to mix common clinical cases with the current technical methods, validation, outcomes, and registry studies as well as the technical, financial and research limitations of FFR-CT analysis to guide the cardiac imaging specialist in evaluating this technique. FFR-CT analysis may help reduce additive functional testing for the smaller proportion of patients with intermediate stenosis undergoing coronary CTA where the atherosclerosis significance is uncertain.
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Keywords: Ischemia; cardiac computed tomography; coronary artery disease; fractional flow reserve; fractional flow reserve derived by computed tomography

Document Type: Research Article

Publication date: April 1, 2019

This article was made available online on February 7, 2019 as a Fast Track article with title: "Practical Clinical Application of Cardiac Computed Tomography–Derived Fractional Flow Reserve".

More about this publication?
  • Cardiovascular Innovations and Applications (CVIA) publishes focused articles and original clinical research that explore novel developments in cardiovascular disease, effective control and rehabilitation in cardiovascular disease, and promote cardiovascular innovations and applications for the betterment of public health globally. The journal publishes basic research that has clinical applicability in order to promote timely communication of the latest insights relating to coronary artery disease, heart failure, hypertension, cardiac arrhythmia, prevention of cardiovascular disease with a heavy emphasis on risk factor modification. Cardiovascular Innovations and Applications is the official journal of the Great Wall International Congress of Cardiology (GW-ICC). It aims to continue the work of the GW-ICC by providing a global scientific communication platform for cardiologists that bridges East and West.

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