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Open Access Circadian Misalignment and Cardiovascular Risk

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This article is Open Access under the terms of the Creative Commons CC BY-NC licence.

All organisms, ranging from single-celled organisms to humans, demonstrate circadian rhythms that are near 24-h patterns that are present independent of environmental cues. Disruption of this process, called circadian misalignment, is associated with deleterious health outcomes. The most extreme example of this misalignment is shift work, and there is evidence suggesting a strong association between shift work and certain cardiovascular outcomes. The outcomes of most studies include obesity, metabolic syndrome, hypertension, type 2 diabetes mellitus, atrial fibrillation, and cardiovascular events. In this article we review the current literature with an emphasis on women’s cardiovascular health. The data are conflicting, and there is a paucity of robust evidence with regard to women’s cardiovascular health and circadian misalignment. More studies are needed to better delineate the sex differences as well as the pathophysiology of the associations between circadian misalignment and cardiovascular diseases so that we can provide patients with more personalized care.
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Keywords: cardiovascular; circadian misalignment; metabolic syndrome; sex; shift work; women

Document Type: Research Article

Publication date: February 1, 2019

This article was made available online on January 16, 2019 as a Fast Track article with title: "Circadian Misalignment and Cardiovascular Risk".

More about this publication?
  • Cardiovascular Innovations and Applications (CVIA) publishes focused articles and original clinical research that explore novel developments in cardiovascular disease, effective control and rehabilitation in cardiovascular disease, and promote cardiovascular innovations and applications for the betterment of public health globally. The journal publishes basic research that has clinical applicability in order to promote timely communication of the latest insights relating to coronary artery disease, heart failure, hypertension, cardiac arrhythmia, prevention of cardiovascular disease with a heavy emphasis on risk factor modification. Cardiovascular Innovations and Applications is the official journal of the Great Wall International Congress of Cardiology (GW-ICC). It aims to continue the work of the GW-ICC by providing a global scientific communication platform for cardiologists that bridges East and West.

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