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Open Access Cardiovascular Immunology Research in Wuhan Union Hospital: Over the Past 25 years

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Cardiovascular immunology research in Wuhan Union Hospital began in 1991. Anti-heart antibodies in dilated cardiomyopathy and acute viral myocarditis began to be reported from 1993. It was found that a new autoantibody against L-type calcium channel results in ventricular tachycardia and sudden death in patients with dilated cardiomyopathy. Through the Intervention Study of Diltiazem in Dilated Cardiomyopathy, diltiazem was verified to reduce mortality and the chronic heart failure hospitalization rate significantly in patients with dilated cardiomyopathy. The autoantibodies against angiotensin II receptor type 1 and α1-adrenoceptor were associated with the increased recurrence of and death from stroke in hypertensive patients. Through many clinical and experimental studies, the functional imbalance of T-cell subsets was suggested to mediate myocardial injury and chronic heart failure, which provided a new theoretical basis for immunoregulation therapy for heart failure. The first antihypertensive polypeptide vaccine (ATRQβ-001) was invented. In addition to these achievements, there will be more research on cardiovascular immunology in Wuhan Union Hospital in the future.
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Keywords: T cells; autoantibody; dilated cardiomyopathy; heart failure; hypertension; vaccine

Document Type: Research Article

Publication date: February 1, 2017

This article was made available online on May 5, 2017 as a Fast Track article with title: "Cardiovascular Immunology Research in Wuhan Union Hospital: Over the Past 25 years".

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  • Cardiovascular Innovations and Applications (CVIA) publishes focused articles and original clinical research that explore novel developments in cardiovascular disease, effective control and rehabilitation in cardiovascular disease, and promote cardiovascular innovations and applications for the betterment of public health globally. The journal publishes basic research that has clinical applicability in order to promote timely communication of the latest insights relating to coronary artery disease, heart failure, hypertension, cardiac arrhythmia, prevention of cardiovascular disease with a heavy emphasis on risk factor modification. Cardiovascular Innovations and Applications is the official journal of the Great Wall International Congress of Cardiology (GW-ICC). It aims to continue the work of the GW-ICC by providing a global scientific communication platform for cardiologists that bridges East and West.

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