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Open Access Prognostic Implications of Echocardiographic Left Ventricular Dyssynchrony

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Normal regional left ventricular (LV) mechanical contraction is synchronous, resulting in efficient ejection. Abnormalities in electrical activation or myocardial diseases may affect the timing of regional contraction, resulting in discoordinated or dyssynchronous contraction, which is inefficient. This article reviews various approaches to quantify dyssynchrony, focusing on LV dyssynchrony, that have been principally related to cardiac resynchronization therapy (CRT). Several attempts have been made to improve patient selection for CRT by use of echocardiographic dyssynchrony; however, none have gained clinical acceptance. This review focuses on the different reasons for the existence LV dyssynchrony, the dyssynchronous strain patterns indicative of CRT response, and the prognostic implications of dyssynchrony. Interest in echocardiographic dyssynchrony remains high because of its mechanistic and prognostic importance. Dyssynchrony may occur from electrical or nonelectrical causes. Patients with a wide QRS complex who have baseline dyssynchrony from electrical delay in general have a favorable response to CRT, whereas patients with nonelectrical dyssynchrony (from contractile heterogeneity or scar) at the baseline have a worse prognosis. New insights into the meaning of mechanical dyssynchrony continue to emerge, and this article reviews the important lessons learned from experience, prognostic implications, and promise for future applications.
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Keywords: Heart failure; echocardiography; pacing therapy; ventricular mechanics

Document Type: Research Article

Publication date: December 1, 2016

This article was made available online on February 9, 2017 as a Fast Track article with title: "Prognostic Implications of Echocardiographic Left Ventricular Dyssynchrony".

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  • Cardiovascular Innovations and Applications (CVIA) publishes focused articles and original clinical research that explore novel developments in cardiovascular disease, effective control and rehabilitation in cardiovascular disease, and promote cardiovascular innovations and applications for the betterment of public health globally. The journal publishes basic research that has clinical applicability in order to promote timely communication of the latest insights relating to coronary artery disease, heart failure, hypertension, cardiac arrhythmia, prevention of cardiovascular disease with a heavy emphasis on risk factor modification. Cardiovascular Innovations and Applications is the official journal of the Great Wall International Congress of Cardiology (GW-ICC). It aims to continue the work of the GW-ICC by providing a global scientific communication platform for cardiologists that bridges East and West.

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