this page is secure
Experimental Study on the Viscoelastic Flow Mixing in Microfluidics
Abstract
Background: The study of blood flow in vessels is always crucial to understand cardiovascular diseases such as arrhythmias, coronary artery disease and deep vein thrombosis. A viscoelastic fluid in a microchannel is modeled for the blood flow study.
Methods: In this paper, we modeled the blood flow through a viscoelastic fluid in a microfluidic channel. The flow properties, especially the flow pattern and transient mixing of two fluid streams in a T-shaped microchannel, are experimentally studied.
Results: It was found that the viscoelastic fluid has a transiently unstable flow pattern compared to the normal Newtonian fluid, and the mixing is also increased due to its elastic property. Similar to the pulsatile blood flow, the fluid is driven under a periodically pulsed stimulus, and the flow pattern and transient mixing are compared at different flow rates and driving period conditions.
Conclusions: The integration of microfluidic technology with the blood flow research could provide a new approach to understand the related disease mechanism, which can also be used to analyze the drug mixing and delivery in the blood flow.
Background: The study of blood flow in vessels is always crucial to understand cardiovascular diseases such as arrhythmias, coronary artery disease and deep vein thrombosis. A viscoelastic fluid in a microchannel is modeled for the blood flow study.
Methods: In this paper, we modeled the blood flow through a viscoelastic fluid in a microfluidic channel. The flow properties, especially the flow pattern and transient mixing of two fluid streams in a T-shaped microchannel, are experimentally studied.
Results: It was found that the viscoelastic fluid has a transiently unstable flow pattern compared to the normal Newtonian fluid, and the mixing is also increased due to its elastic property. Similar to the pulsatile blood flow, the fluid is driven under a periodically pulsed stimulus, and the flow pattern and transient mixing are compared at different flow rates and driving period conditions.
Conclusions: The integration of microfluidic technology with the blood flow research could provide a new approach to understand the related disease mechanism, which can also be used to analyze the drug mixing and delivery in the blood flow.
15 References.
No Supplementary Data.
No Article Media
No Metrics
Keywords: Microfluidics; mixing; viscoelastic flow
Document Type: Original Article
Affiliations: 1: The First Affiliated Hospital of Sun Yat-Sen University, Sun Yat-Sen University, Guangzhou 510080, China 2: School of Physics and Material Science, Guangzhou University, Guangzhou 510006 China
Publication date: January 1, 2021
This article was made available online on December 1, 2020 as a Fast Track article with title: "Experimental Study on the Viscoelastic Flow Mixing in Microfluidics".
- BIO Integration will specifically focus on original, cutting-edge, interdisciplinary contents in the field of biosciences, including medicine, biochemistry, biophysics, bioengineering, biotechnology, etc., which generate hypotheses and questions relevant to the patient and disease and guide the investigations of cellular and molecular medicine. BIO Integration covers new methods, important applications, and new interpretations and treatments of existing data, as well as conventional studies in medicine that can be applied to future theranostic applications.
- Editorial Board
- Information for Authors
- Submit a Paper
- Information for Advertisers
- BIO Integration Aims and Scope
- BIO Integration Journal Information
- BIO Integration Contact Us
- Ingenta Connect is not responsible for the content or availability of external websites
Receive new issue alert