Gleditsia sinensis Extract in Rats Transplanted With Hepatocellular Carcinoma Cells
Anticancer Effects of
The thorns of Gleditsia sinensis have been historically used in Chinese medicine and are considered one of the fundamental therapeutic herbs. Its anticancer effects are currently being explored. Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer and
still requires the development of new drugs with higher efficiency. By using a rat HCC model implanted with cancerous Walker-256 cells, the therapeutic effects of G. sinensis extract (GSE) were assessed, as well as its regulatory effects on miRNAs. GSE significantly restored liver morphology
and dramatically induced cell apoptosis in HCC rats. In addition, miR-21/181b/183 was upregulated in the HCC liver, and the elevation of these miRNAs could be alleviated by both GSE and sorafenib. PTEN/TIMP3/PDCD4 downregulation was consistent with the targets of miR-21/181b/183 in the HCC
liver, and the alteration of these target genes was restored by both GSE and sorafenib. TIMP3 effects on MMP-2/9 expression were also determined. Our present findings indicate the potential of GSE in HCC treatment, and expand the understanding of miRNA-related mechanisms in the anticancer
effects of GSE.
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Gleditsia sinensis extract (GSE);
Hepatocellular carcinoma (HCC)
Document Type: Research Article
Clinical Medical College of Hubei University of Chinese Medicine, Wuhan, P.R. China
College of Pharmacy of Hubei University of Chinese Medicine, Wuhan, P.R. China
Wuhan Hospital of Traditional Chinese Medicine Department of Pediatrics, Wuhan, P.R. China
Infectious Disease of Wuhan Medical Treatment Center, Wuhan, P.R. China
Publication date: August 8, 2019
This article was made available online on April 2, 2019 as a Fast Track article with title: "Anticancer effects of Gleditsia sinensis extract in rats transplanted with hepatocellular carcinoma cells".
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