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Open Access miR-144-3p Targets FosB Proto-oncogene, AP-1 Transcription Factor Subunit (FOSB) to Suppress Proliferation, Migration, and Invasion of PANC-1 Pancreatic Cancer Cells

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This study aimed to investigate the role of miR-144-3p in pancreatic cancer (PC) carcinogenesis and to explore the mechanism of its function in PC. miR-144-3p was downregulated in PC tissues and cells. miR-144-3p overexpression significantly inhibited PC cell proliferation, migration, and invasion. FosB proto-oncogene, AP-1 transcription factor subunit (FOSB) was a target gene of miR-144-3p. miR-144-3p could repress PC cell proliferation, migration, and invasion by inhibiting the expression of FOSB. In conclusion, miR-144-3p plays an important role in PC cell proliferation, migration, and invasion by targeting FOSB. miR-144-3p may provide a new target for the development of therapeutic agents against PC.
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Keywords: Cell invasion; Cell migration; Cell proliferation; FosB proto-oncogene, AP-1 transcription factor subunit (FOSB); Pancreatic cancer (PC); miR-144-3p

Document Type: Research Article

Affiliations: The First Department of General Surgery, Daqing Oilfield General Hospital, Daqing, Heilongjiang, P.R. China

Publication date: 11 June 2018

This article was made available online on 24 June 2017 as a Fast Track article with title: "MiR-144-3p Targets FosB Protooncogene, AP-1 Transcription Factor Subunit (FOSB) to Suppress Proliferation, Migration, and Invasion of PANC-1 Pancreatic Cancer Cells".

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