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Open Access Knockdown of TRIM44 Inhibits the Proliferation and Invasion in Prostate Cancer Cells

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Tripartite motif 44 (TRIM44), a member of the TRIM protein family, has been shown to play a role in tumor development and progression. However, the potential involvement of TRIM44 in prostate cancer has not been fully explored. Therefore, in the present study, we analyzed the expression of TRIM44 in prostate cancer and assessed the role of TRIM44 in the progression of prostate cancer. Our results showed that the expression of TRIM44 was significantly upregulated in human prostate cancer cell lines. In addition, knockdown of TRIM44 significantly inhibited the proliferation, migration, and invasion of prostate cancer cells in vitro, as well as attenuated the tumor growth in vivo. Mechanistic studies showed that knockdown of TRIM44 significantly reduced the levels of phosphorylated PI3K and Akt in PC-3 cells. In conclusion, this study provided evidence that knockdown of TRIM44 inhibited proliferation and invasion in prostate cancer cells, at least in part, through the inactivation of the PI3K/Akt signaling pathway. These results suggest that TRIM44 may be a potential therapeutic target for the treatment of prostate cancer.
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Keywords: Invasion; PI3K/Akt pathway; Prostate cancer; Tripartite motif 44 (TRIM44)

Document Type: Research Article

Affiliations: 1: Department of Echocardiography, First Hospital of Jilin University, Changchun, Jilin, P.R. China 2: Department of Clinical Laboratory, First Hospital of Jilin University, Changchun, Jilin, P.R. China 3: Department of Urology, First Hospital of Jilin University, Changchun, Jilin, P.R. China 4: Department of Andrology, First Hospital of Jilin University, Changchun, Jilin, P.R. China

Publication date: September 21, 2017

This article was made available online on February 3, 2017 as a Fast Track article with title: "Knockdown of TRIM44 Inhibits the Proliferation and Invasion in Prostate Cancer Cells".

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  • Formerly: Oncology Research Incorporating Anti-Cancer Drug Design
    Oncology Research Featuring Preclinical and Clincal Cancer Therapeutics publishes research of the highest quality that contributes to an understanding of cancer in areas of molecular biology, cell biology, biochemistry, biophysics, genetics, biology, endocrinology, and immunology, as well as studies on the mechanism of action of carcinogens and therapeutic agents, reports dealing with cancer prevention and epidemiology, and clinical trials delineating effective new therapeutic regimens.

    From Volume 23, Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics is Open Access under the terms of the Creative Commons CC BY-NC-ND license.

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