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The development of telomerase inhibitors: the G-quartet approach

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Human telomeres, which consist of repeated TTAGGG sequences, have recently become the focus of intense and highly competitive biological research. This scientific interest lies in their unique biological functions: telomeres are essential for genome integrity and appear to play an important role in cellular aging and cancer. As telomerase appears to be selectively expressed in tumors versus normal cells, this enzyme represents a good target for inhibition. Different types of telomerase inhibitors have recently been described. We will present briefly the different strategies that have been proposed to achieve efficient telomerase inhibition, with a special emphasis on G-quartet ligands.
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Keywords: G-quartet; G4-DNA; quadruplex; telomerase inhibitors; telomere

Document Type: Research Article

Affiliations: Centre de Recherche de Vitry-Alfortville, Rhône-Poulenc Rorer, F-94400 Vitry-sur-Seine Cedex, France

Publication date: August 1, 1999

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