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Study of the anti-angiogenic effects of cardiolipin by the aortic ring assay

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Cardiolipin (CL), a phospholipid found in the inner mitochondrial membrane in all cell types, is critical for the function of the electron transport chain. The role of CL is not fully understood, but it is assumed that the molecule maintains membrane potential and architecture and compensates for alterations in homeostasis that could affect the energy metabolism. The objective of this project was to determine the effects of increasing CL concentrations on angiogenic sprouting by using the aortic ring assay model. For this, 5-day-old C57Bl/6 pups were euthanized by cervical dislocation prior to removal of the aortas. The vessels were cleaned, cut in 0.5 mm wide rings, and placed in a collagen growth matrix supplemented with CL. The results revealed a highly significant reduction of sprout growth (both length and quantity) at low, physiological concentrations. In conclusion, the results of this study demonstrate that CL significantly reduces microvessel formation and that it could potentially provide an interesting novel therapeutic target for angiogenesis.
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Keywords: angiogenesis; angiogenèse; aortic ring assay; cardiolipin; cardiolipine; cellules endothéliales; endothelial cells; microvaisseaux; microvessels; modèle d’anneaux aortiques; sprouting

Document Type: Research Article

Publication date: January 1, 2015

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