Skip to main content
padlock icon - secure page this page is secure

Functional contribution of α1D-adrenoceptors in the renal vasculature of left ventricular hypertrophy induced with isoprenaline and caffeine in Wistar–Kyoto rats

Buy Article:

$36.73 + tax (Refund Policy)

This study investigated the role of α1D-adrenoceptor in the modulation of renal haemodynamics in rats with left ventricular hypertrophy (LVH). LVH was established in Wistar–Kyoto (WKY) rats with isoprenaline (5.0 mg·(kg body mass)–1, by subcutaneous injection every 72 h) and caffeine (62 mg·L–1 in drinking water, daily for 14 days). Renal vasoconstrictor responses were measured for noradrenaline (NA), phenylephrine (PE), and methoxamine (ME) before and immediately after low or high dose intrarenal infusions of BMY 7378, a selective α1D-adrenoceptor blocker. The rats with LVH had higher mean arterial blood pressure and circulating NA levels, but lower renal cortical blood perfusion compared with the control group (all P < 0.05). In the LVH group, the magnitude of the renal vasoconstrictor response to ME was blunted, but not the response to NA or PE (P < 0.05), compared with the control group (LVH vs. C, 38% vs. 50%). The magnitude of the drop in the vasoconstrictor responses to NA, PE, and ME in the presence of a higher dose of BMY 7378 was significantly greater in the LVH group compared with the control group (LVH vs. C, 45% vs. 25% for NA, 52% vs. 33% for PE, 66% vs. 53% for ME, all P < 0.05). These findings indicate an impaired renal vasoconstrictor response to adrenergic agonists during LVH. In addition, the α1D-adrenoceptor subtype plays a key role in the modulation of vascular responses in this diseased state.
No Reference information available - sign in for access.
No Citation information available - sign in for access.
No Supplementary Data.
No Article Media
No Metrics

Keywords: BMY 7378; methoxamine; méthoxamine; noradrenaline; noradrénaline; perfusion sanguine corticale rénale; phenylephrine; phényléphrine; renal cortical blood perfusion

Document Type: Research Article

Affiliations: 1: School of Pharmaceutical Sciences, University Sains Malaysia, Penang 11800, Malaysia. 2: Department of Physiology, University College Cork, County Cork, Ireland. 3: Department of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia. 4: Institute for Research in Molecular Medicine (INFORMM), University Sains Malaysia, Minden, Penang, Malaysia.

Publication date: January 1, 2014

More about this publication?
  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more