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Excitation–contraction coupling properties in women with work-related myalgia: a preliminary study

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We investigated the potential role of selected excitation–contraction coupling processes in females with work-related myalgia (WRM) by comparing WRM with healthy controls (CON) using tissue from extensor carpi radialis brevis (ECRB) and trapezius (TRAP) muscles. For the ECRB, age (mean ± SE) was 29.6 ± 3.5 years for CON (n = 9) and 39.2 ± 2.8 years for WRM (n = 13), while for the TRAP, the values were 26.0 ± 2.1 years for CON (n = 7) and 44.6 ± 2.9 years for WRM (n = 11). For the sarcoplasmic reticulum (SR) of the ECRB, WRM displayed concentrations (nmol·(mg protein)−1·min−1) that were lower (P < 0.05) for Total (202 ± 4.4 vs 178 ± 7.1), Basal (34 ± 1.6 vs 30.1 ± 1.3), and maximal Ca2+-ATPase activity (V max, 168 ± 4.9 vs 149 ± 6.3), and Ca2+-uptake (5.06 ± 0.31 vs 4.13 ± 0.29), but not SERCA1a and SERCA2a isoforms, by comparison with CON. When age was incorporated as a co-variant, Total, Basal, and Ca2+-uptake remained different from CON (P < 0.05), but not V max (P = 0.13). For TRAP, none of the ATPase properties differed between groups (P > 0.05) either before or following adjustment for age. No differences (P > 0.05) were observed between the groups for Ca2+-release in the SR for either TRAP or ECRB. Similarly, no deficiencies, regardless of muscle, were noted for either the Na+–K+-ATPase content or the α and β subunit isoform distribution in WRM. This preliminary study provides a basis for further research, with expanded numbers, investigating the hypothesis that abnormalities in SR Ca2+-regulation are involved in the cellular etiology of WRM.
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Keywords: calcium regulation; couplage excitation–contraction; excitation–contraction coupling; extensor carpi radialis brevis; muscle court extenseur radial du carpe; myalgia; myalgie; régulation du calcium; réticulum sarcoplasmique; sarcoplasmic reticulum; trapezius; trapèze; travail; work

Document Type: Research Article

Affiliations: 1: Department of Kinesiology, University of Waterloo, Waterloo, ON N2L 3G1, Canada. 2: Wellington Orthopaedic and Rehabilitation Centre, 86 Dawson Road, Unit 3, Guelph, ON N1H 1A8, Canada. 3: Mind-Body Medicine, The RSI Clinic, 79 St. Clair Avenue East, Toronto, ON M4T 1M6, Canada.

Publication date: January 1, 2014

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