Provider: Ingenta Connect
Database: Ingenta Connect
Content: application/x-research-info-systems
TY - ABST
AU - Sun, Hong-Zhao
AU - Zhao, Shu-Zhen
AU - Ai, Hong-Bin
TI - Microinjection of l-glutamate into the nucleus ambiguus partially inhibits gastric motility through the NMDA receptor – nitric oxide pathway
JO - Canadian Journal of Physiology and Pharmacology
PY - 2014-01-01T00:00:00///
VL - 92
IS - 6
SP - 455
EP - 459
KW - nucleus ambiguus
KW - oxyde nitrique
KW - récepteur NMDA
KW - gastric motility
KW - L-glutamate
KW - motilité gastrique
KW - NMDA receptor
KW - nitric oxide
KW - l-glutamate
KW - noyau ambigu
N2 - We have previously reported that both l-glutamate (l-Glu) and nitric oxide (NO) modulate gastric motility in the nucleus ambiguus (NA). The aim of this study is to explore the potential correlation between the l-Glu and NO. A latex balloon connected to a pressure transducer was inserted
into the pylorus through the fundus of anesthetized male Wistar rats to continuously record changes in gastric smooth muscle contractile curves. Pretreatment with the NO-synthase inhibitor N-nitro-l-arginine methylester (l-NAME) did not completely abolish the inhibitory effect of l-Glu
on gastric motility, but intravenous injection of the ganglionic blocker hexamethonium bromide (Hb) did. By using a specific N-methyl-d-aspartic acid (NMDA) receptor antagonist, we blocked the inhibitory effect of the NO-donor sodium nitroprusside (SNP) on gastric motility. These results
suggest that microinjections of l-Glu into the NA inhibits gastric motility by activating the cholinergic preganglionic neurons, partially through the NMDA receptor – NO pathway.
UR - https://www.ingentaconnect.com/content/cndscipub/cjpp/2014/00000092/00000006/art00005
M3 - doi:10.1139/cjpp-2013-0413
UR - https://doi.org/10.1139/cjpp-2013-0413
ER -