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Microinjection of l-glutamate into the nucleus ambiguus partially inhibits gastric motility through the NMDA receptor – nitric oxide pathway

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We have previously reported that both l-glutamate (l-Glu) and nitric oxide (NO) modulate gastric motility in the nucleus ambiguus (NA). The aim of this study is to explore the potential correlation between the l-Glu and NO. A latex balloon connected to a pressure transducer was inserted into the pylorus through the fundus of anesthetized male Wistar rats to continuously record changes in gastric smooth muscle contractile curves. Pretreatment with the NO-synthase inhibitor N-nitro-l-arginine methylester (l-NAME) did not completely abolish the inhibitory effect of l-Glu on gastric motility, but intravenous injection of the ganglionic blocker hexamethonium bromide (Hb) did. By using a specific N-methyl-d-aspartic acid (NMDA) receptor antagonist, we blocked the inhibitory effect of the NO-donor sodium nitroprusside (SNP) on gastric motility. These results suggest that microinjections of l-Glu into the NA inhibits gastric motility by activating the cholinergic preganglionic neurons, partially through the NMDA receptor – NO pathway.
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Keywords: L-glutamate; NMDA receptor; gastric motility; l-glutamate; motilité gastrique; nitric oxide; noyau ambigu; nucleus ambiguus; oxyde nitrique; récepteur NMDA

Document Type: Research Article

Affiliations: 1: College of Life Science, Qi Lu Normal University, No. 36, Lishan Road, Jinan, Shandong 250013, P.R. China. 2: Biotechnology Research Center, Shandong Academy of Agricultural Sciences, Jinan, Shandong 250100, P.R. China. 3: Key Laboratory of Animal Resistance, College of Life Science, Shandong Normal University, No. 88, East Wenhua Road, Jinan, Shandong 250014, P.R. China.

Publication date: January 1, 2014

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