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Enhanced expression of salusin-β contributes to progression of atherosclerosis in LDL receptor deficient mice

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Atherosclerosis is an important underlying pathology of cardiovascular diseases. The aim of this study was to observe the expression of salusin-β, a new vasoactive peptide, in vascular tissues of low-density lipoprotein receptor deficient (LDLR–/–) mice, and to evaluate the effect of salusin-β on the development of atherosclerosis in LDLR–/– mice. Six-week-old, male LDLR–/– mice were subcutaneously injected with salusin-β or the vehicle, once a day for 12 weeks. The expressions of salusin-β in both mRNA and peptide levels were determined by reverse transcription – polymerase chain reaction, Western blot, and immunohistochemistry. Atherosclerotic lesions were analyzed by staining with hematoxylin and eosin or oil red O. Our results showed that expression of salusin-β in mRNA and salusin-β peptide levels were enhanced in LDLR–/– mice. Subcutaneous injection of salusin-β significantly aggravated the atherosclerotic lesions, and increased lipid deposits in the arteries of LDLR–/– mice. Moreover, salusin-β significantly increased the serum level of low-density lipoprotein cholesterol, but not total cholesterol, triglycerides, or high-density lipoprotein cholesterol. These results suggest that the enhanced expression of salusin-β contributes to progression of atherosclerosis in LDLR–/– mice by up-regulating the serum low-density lipoprotein cholesterol level. This study provides a potential therapeutic target for the prevention and treatment of atherosclerosis.
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Keywords: atherosclerosis; athérosclérose; mice; peptide; salusin-β; salusine-β; souris

Document Type: Research Article

Affiliations: 1: Department of Pharmacology, Xuzhou Medical College, Xuzhou 221009, P.R. China. 2: Department of Anesthetic Pharmacology, Xuzhou Medical College, Xuzhou 221002, P.R. China.

Publication date: April 1, 2012

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