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Hypothyroidism does not affect the dihydropyridine sensitivity of precontracted murine uterus

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Thyroid hormones are known to influence various processes of cell differentiation. Recently, it was reported that hypothyroidism reduces the sensitivity to Ca2+-channel antagonists in the rat uterus. We examined the sensitivity to dihydropyridines of the uterus from mice that had reduced thyroid hormone levels. Isradipine relaxed with the same potency precontracted uterine muscle strips from control and hypothyroid mice, independently from a pseudo-pregnant state. These results demonstrate that hypothyroidism does not change dihydropyridine sensitivity (i.e., the pattern of Ca2+-channel expression) in the murine uterus.Key words: uterus, smooth muscle, Ca2+ channel, isradipine.

On sait que les hormones thyroïdiennes influent sur plusieurs processus de la différenciation cellulaire. Or, on a récemment rapporté que l'hypothyroïdie réduisait la sensibilité aux antagonistes des canaux calciques dans l'utérus de la rate. Dans la présente étude, nous avons examiné la sensibilité de l'utérus aux dihydropyridines chez les souris présentant des taux d'hormones thyroïdiennes réduits. Chez les souris hypothyroïdiennes et les souris normales, l'isradipine a eu le même effet relaxant sur les bandes de muscles utérins précontractés, et ce, indépendamment de l'état de pseudogestation de l'animal. Ces résultats démontrent que l'hypothyroïdie n'affecte pas la sensibilité aux dihydropyridines, c'est-à-dire le mode d'expression des canaux calciques, dans l'utérus murin.Mots clés : utérus, muscles lisses, canaux calciques, isradipine[Traduit par la Rédaction]
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Document Type: Research Article

Publication date: September 1, 2003

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